منابع مشابه
Nuclear reprogramming in cells.
Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these ...
متن کاملReprogramming Cancer Stem Cells
The use of reprogramming technologies have been developed to revert normal somatic differentiated cells (NSDCs), such as fibroblasts, into patient-specific induced-pluripotent stem cells (iPSCs) that can be easily differentiated into different lineages, potentially useful in cell therapy and regenerative medicine. The method invented by Yamanaka [1] allows inserting into the cell, by plasmid tr...
متن کاملReprogramming mammalian somatic cells.
Somatic cell nuclear transfer (SCNT), the technique commonly known as cloning, permits transformation of a somatic cell into an undifferentiated zygote with the potential to develop into a newborn animal (i.e., a clone). In somatic cells, chromatin is programmed to repress most genes and express some, depending on the tissue. It is evident that the enucleated oocyte provides the environment in ...
متن کاملStem Cells and Nuclear Reprogramming
1Renova Life Inc., University of Maryland, College Park, MD 20742, USA 2Center for Regenerative Biology, University of Connecticut, Storrs, CT 06269, USA 3Consorzio di Ricerca e Sperimentazione per gli Allevatori (CRSA), 00161 Rome, Italy 4Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan 5Department of Animal Science, National Pingtung University of Sc...
متن کاملCellular reprogramming of somatic cells.
The process of 'cell reprogramming' can be achieved by somatic cell nuclear transfer, cell fusion with embryonic stem cells, exposure to stem cell extracts, or by inducing pluripotentcy mediated by defined factors giving rise to what are termed induced pluripotent stem cells. More recently, the fate of a somatic cell can be directly induced to uptake other cell fates, termed lineage-specific re...
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ژورنال
عنوان ژورنال: Science
سال: 2008
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.322.5909.1766